Wong H R, Doughty L A, Wedel N, White M, Nelson B J, Havrilla N, Carcillo J A
Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA.
Pediatr Infect Dis J. 1995 Dec;14(12):1087-91. doi: 10.1097/00006454-199512000-00011.
Bactericidal/permeability-increasing protein (BPI) is a neutrophil azurophilic granule component that is bactericidal towards Gram-negative bacteria and inhibits lipopolysaccharide-mediated inflammatory responses. We conducted a prospective study to measure plasma BPI concentrations in 36 critically ill children with and without the sepsis syndrome. Plasma BPI concentrations ranged from 0.5 to 452 ng/ml. Patients with the sepsis syndrome had higher median plasma BPI concentrations than critically ill controls (5.1 vs. 1.8 ng/ml, P = 0.006). Patients with organ system failure had higher median plasma BPI concentrations than those with no organ system failure (4.5 vs. 1.3 ng/ml, P = 0.001). Plasma BPI concentrations were positively associated with pediatric risk of mortality score (P = 0.03, rs = 0.4). These data provide the first clinical insights regarding the role of endogenous BPI production in critically ill children and suggest that BPI may play an important role in host defenses.
杀菌/通透性增加蛋白（BPI）是中性粒细胞嗜天青颗粒的一种成分，对革兰氏阴性菌具有杀菌作用，并能抑制脂多糖介导的炎症反应。我们进行了一项前瞻性研究，以测量36名患有和未患有脓毒症综合征的危重症儿童的血浆BPI浓度。血浆BPI浓度范围为0.5至452 ng/ml。患有脓毒症综合征的患者血浆BPI浓度中位数高于危重症对照组（5.1对1.8 ng/ml，P = 0.006）。出现器官系统衰竭的患者血浆BPI浓度中位数高于未出现器官系统衰竭的患者（4.5对1.3 ng/ml，P = 0.001）。血浆BPI浓度与儿童死亡风险评分呈正相关（P = 0.03，rs = 0.4）。这些数据首次提供了关于内源性BPI产生在危重症儿童中作用的临床见解，并表明BPI可能在宿主防御中发挥重要作用。
