Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Duke University, 2424 Hock Plaza, Suite 504, DUMC Box 2739, Durham, NC 27710, USA.
Clin Perinatol. 2010 Jun;37(2):307-37. doi: 10.1016/j.clp.2010.04.001.
Neonatal sepsis continues to take a devastating toll globally. Although adequate to protect against invasive infection in most newborns, the distinct function of neonatal innate host defense coupled with impairments in adaptive immune responses increases the likelihood of acquiring infection early in life, with subsequent rapid dissemination and death. Unique differences exist between neonates and older populations with respect to the capacity, quantity, and quality of innate host responses to pathogens. Recent characterization of the age-dependent maturation of neonatal innate immune function has identified novel translational approaches that may lead to improved diagnostic, prophylactic, and therapeutic modalities.
新生儿败血症在全球范围内仍造成严重影响。虽然新生儿的固有宿主防御功能足以抵御大多数侵袭性感染，但由于适应性免疫反应受损，新生儿更容易在生命早期感染，并迅速传播和死亡。新生儿与老年人在固有宿主对病原体的反应能力、数量和质量方面存在独特差异。最近对新生儿固有免疫功能随年龄变化的成熟特征的描述，确定了可能改进诊断、预防和治疗方法的新的转化方法。
