抗利尿激素分泌转基因小鼠的警觉性改变。

Altered alertness of vasopressin-secreting transgenic mice.

作者信息

Miller M, Haroutunian V, Wiltshire-Clement M

机构信息

Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA.

出版信息

Peptides. 1995;16(8):1329-33. doi: 10.1016/0196-9781(95)02047-0.

DOI:10.1016/0196-9781(95)02047-0

PMID:8745040

Abstract

We evaluated behavior and cognitive performance in a line of transgenic mice that overexpress the rat gene for vasopressin. Open field testing revealed greatest habituation in homozygous mice. Passive avoidance performance indicated equal learning and memory ability of transgenic compared to normal mice. Drinking behavior following exposure to 10% sucrose solution suggested diminished neophobia in homozygous mice. These observations are consistent with enhanced attention and alertness in the transgenic animals and support prior observations on the effects of vasopressin on behavior and cognitive function.

摘要

我们评估了一组过表达大鼠血管加压素基因的转基因小鼠的行为和认知表现。旷场试验显示纯合子小鼠的习惯化程度最高。被动回避试验表明，与正常小鼠相比，转基因小鼠的学习和记忆能力相当。接触10%蔗糖溶液后的饮水行为表明，纯合子小鼠的新物恐惧症有所减轻。这些观察结果与转基因动物注意力和警觉性增强一致，并支持先前关于血管加压素对行为和认知功能影响的观察结果。