Wienberg J, Stanyon R
Department of Pathology, Cambridge University, UK.
Curr Opin Genet Dev. 1995 Dec;5(6):792-7. doi: 10.1016/0959-437x(95)80013-u.
Chromosome painting has become a routine tool in comparative cytogenetics. The utility of interspecies chromosome painting has been demonstrated in taxa characterized by highly rearranged karyotypes such as in rodents and lesser apes. Chromosome painting also provides a new level of precision in comparative genome analysis for eliminating errors of confounding convergence with homology. Recent results hold promise that molecular cytogenetics will make a significant contribution to the understanding of the major features of genome evolution.
染色体描绘已成为比较细胞遗传学中的常规工具。种间染色体描绘的效用已在具有高度重排核型的分类群中得到证明，如啮齿动物和小型猿类。染色体描绘还为比较基因组分析提供了新的精确水平，以消除与同源性混淆趋同的错误。最近的结果表明，分子细胞遗传学有望对理解基因组进化的主要特征做出重大贡献。
