Jacobs L
J Neurol Neurosurg Psychiatry. 1977 Apr;40(4):331-5. doi: 10.1136/jnnp.40.4.331.
Seventeen of 33 patients (51.5%) with normal pressure hydrocephalus were discovered to have diabetes mellitus. This was significantly greater than the 12.1% incidence found in age-matched control subjects. The diabetes was not accounted for either by the patients' ages nor by their physical inactivity due to hospitalisation. Diabetes mellitus concurrent with normal pressure hydrocephalus may result from involvement of hypothalamic and brainstem autonomic structures by the expanding ventricles during the evolution of hydrocephalus.
33例正常压力脑积水患者中有17例(51.5%)被发现患有糖尿病。这显著高于年龄匹配的对照受试者中12.1%的发病率。糖尿病既不能用患者的年龄来解释,也不能用因住院导致的身体活动不足来解释。正常压力脑积水并发糖尿病可能是由于脑积水发展过程中扩大的脑室累及下丘脑和脑干自主神经结构所致。