Tsai T T, Lasker A, Zee D S
Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan.
Neuropsychologia. 1995 Dec;33(12):1617-26. doi: 10.1016/0028-3932(95)00094-1.
Studies of eye movements in patients with Huntington's disease (HD) have suggested that frontal lobe-basal ganglia structures are more involved in HD than the parietal lobes. To test this hypothesis further we compared the ability of HD patients and normal subjects to direct "covert" visual attention, using saccade latency and thumb press reaction time tasks that have been shown to be sensitive to parietal lobe dysfunction. Subjects were instructed to move their eyes or to press a button when a peripheral target was illuminated. The peripheral stimulus appeared at various intervals after the appearance of a central arrow(s) that pointed in the direction of the target (valid cue), in the opposite direction (invalid cue), or pointed simultaneously in both directions (neutral cue). For both saccade and thumb press paradigms, the difference in the latencies for trials with invalid and valid cues was the same in HD patients and normals. These findings suggest that the ability to direct visual attention is normal in HD and are compatible with the hypothesis that in HD, frontal-basal-ganglia circuits are more affected than parietal lobe pathways.
对亨廷顿舞蹈症（HD）患者眼球运动的研究表明，相较于顶叶，额叶 - 基底神经节结构在HD中受累程度更高。为进一步验证这一假设，我们使用已被证明对顶叶功能障碍敏感的扫视潜伏期和拇指按压反应时间任务，比较了HD患者和正常受试者引导“隐蔽”视觉注意力的能力。当外周目标被照亮时，受试者被指示移动眼睛或按下按钮。外周刺激在指向目标方向（有效线索）、相反方向（无效线索）或同时指向两个方向（中性线索）的中央箭头出现后的不同时间间隔出现。对于扫视和拇指按压范式，HD患者和正常人中无效线索和有效线索试验的潜伏期差异相同。这些发现表明，HD患者引导视觉注意力的能力正常，这与HD中额叶 - 基底神经节回路比顶叶通路受影响更大的假设相符。
