Lasker A G, Zee D S, Hain T C, Folstein S E, Singer H S
Neurology. 1987 Mar;37(3):364-70. doi: 10.1212/wnl.37.3.364.
We recorded saccadic eye movements in patients mildly affected with Huntington's disease. Most showed an increase in saccade latencies that was greater for saccades made on command than to the sudden appearance of a visual target. All patients showed excessive distractibility during attempted fixation. They had particular difficulty suppressing a saccade to a suddenly appearing visual target when simultaneously trying to initiate a saccade in the opposite direction. Our results are compatible with a posited role of the basal ganglia in both the initiation of volitional saccades and in the maintenance of fixation. Saccade abnormalities--especially distractibility--are sensitive but probably not specific indicators of Huntington's disease.
我们记录了轻度亨廷顿舞蹈症患者的眼球跳动。大多数患者的扫视潜伏期增加，与视觉目标突然出现时相比，指令性扫视的潜伏期增加更为明显。所有患者在试图注视时均表现出过度易分心。当他们同时试图向相反方向发起扫视时，尤其难以抑制对突然出现的视觉目标的扫视。我们的结果与基底神经节在自主性扫视启动和注视维持中所假定的作用相符。扫视异常——尤其是易分心——是亨廷顿舞蹈症敏感但可能并非特异性的指标。
