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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Martin M I, Goicoechea C, Ormazabal M J, Alfaro M J

Departamento de Farmacologia, Facultad de Medicina, U. Complutense, Madrid, Spain.

Gen Pharmacol. 1995 Dec;26(8):1695-9. doi: 10.1016/0306-3623(95)00044-5.

The interaction of intraperitoneal administration of salmon-calcitonin with opioids was studied. The study was carried out using guinea pig ileum (mu and kappa-opioid receptors), rabbit vas deferens (kappa-opioid receptors) and mouse vas deferens (delta-opioid receptors), and selective mu, delta and kappa agonists were used in the pertinent tissues. 2. The treatment with salmon-calcitonin increased, in a dose-dependent manner, the effect of U-50,488H in guinea pig ileum and rabbit vas deferens and the effects of [D-Pen2, D-Pen5] enkephalin in mouse vas deferens. 3. The treatment with analgesic doses of salmon-calcitonin enhances the in vitro effects of kappa- and delta-opioid agonists. The increase of the effectiveness of the opioid agonists may be one of the mechanisms involved on the analgesia induced by salmon-calcitonin.

研究了腹腔注射鲑鱼降钙素与阿片类药物的相互作用。该研究使用豚鼠回肠（μ和κ阿片受体）、兔输精管（κ阿片受体）和小鼠输精管（δ阿片受体）进行，并在相关组织中使用了选择性μ、δ和κ激动剂。2. 鲑鱼降钙素处理以剂量依赖性方式增强了U - 50,488H在豚鼠回肠和兔输精管中的作用以及[D - Pen2，D - Pen5]脑啡肽在小鼠输精管中的作用。3. 镇痛剂量的鲑鱼降钙素处理增强了κ和δ阿片激动剂的体外作用。阿片激动剂有效性的增加可能是鲑鱼降钙素诱导镇痛作用的相关机制之一。

Martin M I, Goicoechea C, Ormazabal M J, Alfaro M J

Departamento de Farmacologia, Facultad de Medicina, U. Complutense, Madrid, Spain.

Gen Pharmacol. 1995 Dec;26(8):1695-9. doi: 10.1016/0306-3623(95)00044-5.

The interaction of intraperitoneal administration of salmon-calcitonin with opioids was studied. The study was carried out using guinea pig ileum (mu and kappa-opioid receptors), rabbit vas deferens (kappa-opioid receptors) and mouse vas deferens (delta-opioid receptors), and selective mu, delta and kappa agonists were used in the pertinent tissues. 2. The treatment with salmon-calcitonin increased, in a dose-dependent manner, the effect of U-50,488H in guinea pig ileum and rabbit vas deferens and the effects of [D-Pen2, D-Pen5] enkephalin in mouse vas deferens. 3. The treatment with analgesic doses of salmon-calcitonin enhances the in vitro effects of kappa- and delta-opioid agonists. The increase of the effectiveness of the opioid agonists may be one of the mechanisms involved on the analgesia induced by salmon-calcitonin.

研究了腹腔注射鲑鱼降钙素与阿片类药物的相互作用。该研究使用豚鼠回肠（μ和κ阿片受体）、兔输精管（κ阿片受体）和小鼠输精管（δ阿片受体）进行，并在相关组织中使用了选择性μ、δ和κ激动剂。2. 鲑鱼降钙素处理以剂量依赖性方式增强了U - 50,488H在豚鼠回肠和兔输精管中的作用以及[D - Pen2，D - Pen5]脑啡肽在小鼠输精管中的作用。3. 镇痛剂量的鲑鱼降钙素处理增强了κ和δ阿片激动剂的体外作用。阿片激动剂有效性的增加可能是鲑鱼降钙素诱导镇痛作用的相关机制之一。