• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鲑鱼降钙素与μ、δ和κ阿片样激动剂相互作用的体外研究。

In vitro study of the interaction of salmon calcitonin with mu, delta and kappa opioid agonists.

作者信息

Martín M I, Alfaro M J, Goicoechea C, Colado M I

机构信息

Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Spain.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1993 Mar;347(3):324-8. doi: 10.1007/BF00167452.

DOI:10.1007/BF00167452
PMID:8386807
Abstract

A possible interaction of salmon-calcitonin with opioid systems was studied in isolated tissues. Neurogenic contractions were elicited by electrical stimulation in guinea-pig ileum myenteric plexus-longitudinal muscle strips, rabbit vas deferens and mouse vas deferens. Bremazocine inhibited neurogenic contractions in all three tissues (presumably through kappa-receptors) [D-Pen2, D-Pen5]enkephalin and [Met5]enkephalin inhibited contractions in mouse vas deferens (presumably through delta-receptors), and [D-Ala2, N-Me-Phe4, Gly5-ol]enkephalin (DAMGO) inhibited contractions in guinea-pig ileum and mouse vas deferens (presumably through mu-receptors). All inhibitory effects were concentration-dependent. Salmon-calcitonin 0.1 IU/ml increased the effect of bremazocine in guinea-pig ileum and rabbit vas deferens and also increased the effects of [D-Pen2, D-Pen5]enkephalin and [Met5]enkephalin in mouse vas deferens. In contrast, salmon-calcitonin up to 0.4 IU/ml did not change the effect of bremazocine in mouse vas deferens and the effect of DAMGO in guinea-pig ileum and mouse vas deferens. It is concluded that salmon-calcitonin enhances agonist effects at opioid kappa- and delta- but not at opioid mu-receptors. The level of this interaction remains to be elucidated. The interaction may be the basis of the analgesic effect of salmon-calcitonin in vivo.

摘要

在离体组织中研究了鲑鱼降钙素与阿片样物质系统之间可能的相互作用。通过电刺激豚鼠回肠肌间神经丛 - 纵肌条、兔输精管和小鼠输精管引发神经源性收缩。布瑞马唑辛抑制所有这三种组织中的神经源性收缩（可能通过κ受体）；[D - Pen2，D - Pen5]脑啡肽和[Met5]脑啡肽抑制小鼠输精管中的收缩（可能通过δ受体），并且[D - Ala2，N - Me - Phe4，Gly5 - ol]脑啡肽（DAMGO）抑制豚鼠回肠和小鼠输精管中的收缩（可能通过μ受体）。所有抑制作用均呈浓度依赖性。0.1 IU/ml的鲑鱼降钙素增强了布瑞马唑辛在豚鼠回肠和兔输精管中的作用，也增强了[D - Pen2，D - Pen5]脑啡肽和[Met5]脑啡肽在小鼠输精管中的作用。相比之下，高达0.4 IU/ml的鲑鱼降钙素并未改变布瑞马唑辛在小鼠输精管中的作用以及DAMGO在豚鼠回肠和小鼠输精管中的作用。得出的结论是，鲑鱼降钙素增强阿片样物质κ和δ受体而非μ受体处的激动剂作用。这种相互作用的程度仍有待阐明。这种相互作用可能是鲑鱼降钙素在体内镇痛作用的基础。

相似文献

1
In vitro study of the interaction of salmon calcitonin with mu, delta and kappa opioid agonists.鲑鱼降钙素与μ、δ和κ阿片样激动剂相互作用的体外研究。
Naunyn Schmiedebergs Arch Pharmacol. 1993 Mar;347(3):324-8. doi: 10.1007/BF00167452.
2
Effect of the intraperitoneal administration of salmon-calcitonin on the "in vitro" actions of opioid agonists.腹腔注射鲑鱼降钙素对阿片类激动剂“体外”作用的影响。
Gen Pharmacol. 1995 Dec;26(8):1695-9. doi: 10.1016/0306-3623(95)00044-5.
3
Evidence for lack of modulation of mu-opioid agonist action by delta-opioid agonists in the mouse vas deferens and guinea-pig ileum.在小鼠输精管和豚鼠回肠中缺乏δ-阿片样激动剂对μ-阿片样激动剂作用调节的证据。
Br J Pharmacol. 1995 Mar;114(5):1064-8. doi: 10.1111/j.1476-5381.1995.tb13314.x.
4
[Cys(O2NH2)2]enkephalin analogues and dalargin: selectivity for delta-opioid receptors.[半胱氨酸（O2NH2）2]脑啡肽类似物与达乐精：对δ阿片受体的选择性
Eur J Pharmacol. 1996 May 23;304(1-3):99-108. doi: 10.1016/0014-2999(96)00083-0.
5
Effect of opioid receptor subtype-selective agonists on purinergic and adrenergic components of neurogenic contractions of mouse vas deferens.阿片受体亚型选择性激动剂对小鼠输精管神经源性收缩中嘌呤能和肾上腺素能成分的影响。
Br J Pharmacol. 1993 Feb;108(2):443-7. doi: 10.1111/j.1476-5381.1993.tb12823.x.
6
Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor.阿片肽类似物作为δ受体激动剂和拮抗剂的选择性。
Br J Pharmacol. 1984 Sep;83(1):271-9. doi: 10.1111/j.1476-5381.1984.tb10143.x.
7
Determination of the receptor selectivity of opioid agonists in the guinea-pig ileum and mouse vas deferens by use of beta-funaltrexamine.使用β-芬太尼环唑来测定豚鼠回肠和小鼠输精管中阿片类激动剂的受体选择性。
Br J Pharmacol. 1985 Dec;86(4):899-904. doi: 10.1111/j.1476-5381.1985.tb11112.x.
8
Two new opioid delta-receptor ligands: a highly selective agonist and a potent selective antagonist in in vitro isolated preparations.两种新型阿片δ受体配体：体外分离制剂中的一种高选择性激动剂和一种强效选择性拮抗剂。
Jpn J Pharmacol. 1984 Dec;36(4):485-9. doi: 10.1254/jjp.36.485.
9
The choice of opiate receptor subtype by neo-endorphins.新内啡肽对阿片受体亚型的选择。
Eur J Pharmacol. 1982 Apr 23;79(3-4):301-5. doi: 10.1016/0014-2999(82)90636-7.
10
Opioid profiles of Cys2-containing enkephalin analogues.含半胱氨酸2的脑啡肽类似物的阿片样物质特性
Eur J Pharmacol. 2004 Sep 13;498(1-3):249-56. doi: 10.1016/j.ejphar.2004.07.059.

引用本文的文献

1
Influence of pertussis toxin on the calcitonin-opioid interaction in isolated tissues.百日咳毒素对分离组织中降钙素 - 阿片样物质相互作用的影响。
Br J Pharmacol. 1996 Nov;119(5):804-6. doi: 10.1111/j.1476-5381.1996.tb15743.x.

本文引用的文献

1
Separation of the longitudinal muscle of the rabbit's ileum as a broad sheet.将兔回肠的纵行肌分离成宽片状。
J Physiol. 1954 Aug 27;125(2):53-5P.
2
Subarachnoid injection of salmon calcitonin induces analgesia in man.蛛网膜下腔注射鲑鱼降钙素可在人体中诱导镇痛作用。
Eur J Pharmacol. 1982 Mar 12;78(3):381-2. doi: 10.1016/0014-2999(82)90044-9.
3
Antinociceptive activity of salmon calcitonin injected intrathecally in the rat.鞘内注射鲑鱼降钙素在大鼠中的抗伤害感受活性。
Neurosci Lett. 1984 Mar 23;45(2):135-9. doi: 10.1016/0304-3940(84)90088-0.
4
Interrelationships between calcitonin and other modulators of feeding behavior.降钙素与其他进食行为调节因子之间的相互关系。
Psychopharmacol Bull. 1984 Summer;20(3):463-5.
5
Reduction in opiate receptor reserve in morphine tolerant guinea pig ilea.吗啡耐受豚鼠回肠中阿片受体储备的减少。
Life Sci. 1982;31(16-17):1687-90. doi: 10.1016/0024-3205(82)90186-2.
6
Rabbit vas deferens: a specific bioassay for opioid kappa-receptor agonists.兔输精管：一种用于阿片κ受体激动剂的特异性生物测定法。
Eur J Pharmacol. 1981 Jul 17;73(2-3):235-6. doi: 10.1016/0014-2999(81)90098-4.
7
Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors.在μ-阿片受体上具有选择性激动剂活性的β-促脂解素61-64类似物。
Eur J Pharmacol. 1981 Apr 9;70(4):531-40. doi: 10.1016/0014-2999(81)90364-2.
8
The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone.纳曲酮富马酸甲酯衍生物的不可逆麻醉拮抗和可逆激动特性。
Eur J Pharmacol. 1981 Apr 9;70(4):445-51. doi: 10.1016/0014-2999(81)90355-1.
9
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.小鼠输精管和豚鼠回肠中强啡肽选择性κ受体的比较。备用受体分数作为效力的决定因素。
Mol Pharmacol. 1983 Jan;23(1):36-43.
10
The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties.具有不同激动剂和拮抗剂特性的麻醉性镇痛药的结合光谱。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Jun;319(3):197-205. doi: 10.1007/BF00495865.