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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

de Diego A, Cortijo J, Villagrasa V, Perpina M, Morcillo E J

Departament de Farmacologia, Facultat de Medicina i Odontologia, Universitat de Valencia, Spain.

Gen Pharmacol. 1995 Dec;26(8):1747-55. doi: 10.1016/0306-3623(95)00075-5.

H-7, a protein kinase C inhibitor, fully inhibited the spontaneous and stimulated (KCl 20 mM or histamine 0.5 mM) tone of trachea from normal and sensitized guinea pig. 2. H-7 depressed the concentration-contraction curves to KCl, histamine or 5-hydroxytryptamine in epithelium-denuded, indomethacin-treated, trachea from normal and sensitized guinea pigs while responses to CaCl2 (in Ca2+ -free, K+ -depolarized tissues) and acetylcholine were not affected. 3. H-7 (100 microM did not depress Ca2+ (20 microM-induced contraction of Triton X-100 skinned trachea. 4. These results suggest the involvement of PKC in the maintenance of spontaneous tone and spasmogenic responses of guinea pig trachea.

蛋白激酶C抑制剂H-7完全抑制正常和致敏豚鼠气管的自发性和刺激性（20 mM氯化钾或0.5 mM组胺）张力。2. H-7使正常和致敏豚鼠经上皮剥脱、消炎痛处理的气管对氯化钾、组胺或5-羟色胺的浓度-收缩曲线降低，而对氯化钙（在无钙、钾去极化组织中）和乙酰胆碱的反应不受影响。3. 100微摩尔的H-7不降低20微摩尔钙离子诱导的Triton X-100透皮气管收缩。4. 这些结果提示蛋白激酶C参与豚鼠气管自发性张力和致痉反应的维持。

de Diego A, Cortijo J, Villagrasa V, Perpina M, Morcillo E J

Departament de Farmacologia, Facultat de Medicina i Odontologia, Universitat de Valencia, Spain.

Gen Pharmacol. 1995 Dec;26(8):1747-55. doi: 10.1016/0306-3623(95)00075-5.

H-7, a protein kinase C inhibitor, fully inhibited the spontaneous and stimulated (KCl 20 mM or histamine 0.5 mM) tone of trachea from normal and sensitized guinea pig. 2. H-7 depressed the concentration-contraction curves to KCl, histamine or 5-hydroxytryptamine in epithelium-denuded, indomethacin-treated, trachea from normal and sensitized guinea pigs while responses to CaCl2 (in Ca2+ -free, K+ -depolarized tissues) and acetylcholine were not affected. 3. H-7 (100 microM did not depress Ca2+ (20 microM-induced contraction of Triton X-100 skinned trachea. 4. These results suggest the involvement of PKC in the maintenance of spontaneous tone and spasmogenic responses of guinea pig trachea.

蛋白激酶C抑制剂H-7完全抑制正常和致敏豚鼠气管的自发性和刺激性（20 mM氯化钾或0.5 mM组胺）张力。2. H-7使正常和致敏豚鼠经上皮剥脱、消炎痛处理的气管对氯化钾、组胺或5-羟色胺的浓度-收缩曲线降低，而对氯化钙（在无钙、钾去极化组织中）和乙酰胆碱的反应不受影响。3. 100微摩尔的H-7不降低20微摩尔钙离子诱导的Triton X-100透皮气管收缩。4. 这些结果提示蛋白激酶C参与豚鼠气管自发性张力和致痉反应的维持。