Yamada Y, Fushimi H, Inoue T, Matsuyama Y, Kameyama M, Minami T, Okazaki Y, Noguchi Y, Kasama T
Department of Internal Medicine, Sumitomo Hospital, Osaka, Japan.
Diabetes Res Clin Pract. 1995 Oct;30(1):37-42. doi: 10.1016/0168-8227(95)01139-0.
To evaluate the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are polyunsaturated fatty acids, on diabetic osteopenia, we measured the bone fragility in streptozotocin-induced diabetic rats. The fragility of femur was increased in diabetic rats, which was prevented in part by EPA or DHA. Moreover, EPA prevented osteopenia even in diabetic rats fed a low zinc feed, which was a potent accelerator of diabetic osteopenia. Plasma alkaline phosphatase activity and parathyroid hormone level showed no difference between the two groups of diabetic rats with or without EPA. Urinary excretion of calcium and phosphate was increased and plasma inorganic phosphate level was high in diabetic rats, suggesting severe mineral loss. In diabetic rats fed EPA, although urinary and plasma calcium levels did not change significantly, urinary phosphate excretion and plasma inorganic phosphate concentration were slightly lowered, which suggested that EPA may have an effect in suppressing phosphate release from bones in diabetic rats. These data suggest that EPA and DHA could be effective on diabetic osteopenia, but to elucidate the precise mechanisms, further examinations will be needed.
为了评估多不饱和脂肪酸二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）对糖尿病性骨质减少的影响，我们测量了链脲佐菌素诱导的糖尿病大鼠的骨脆性。糖尿病大鼠股骨的脆性增加，而EPA或DHA可部分预防这种情况。此外，即使在喂食低锌饲料（这是糖尿病性骨质减少的强效促进因素）的糖尿病大鼠中，EPA也能预防骨质减少。两组糖尿病大鼠（有或没有EPA）的血浆碱性磷酸酶活性和甲状旁腺激素水平没有差异。糖尿病大鼠的尿钙和磷酸盐排泄增加，血浆无机磷酸盐水平升高，提示严重的矿物质流失。在喂食EPA的糖尿病大鼠中，虽然尿钙和血钙水平没有明显变化，但尿磷酸盐排泄和血浆无机磷酸盐浓度略有降低，这表明EPA可能对抑制糖尿病大鼠骨骼中的磷酸盐释放有作用。这些数据表明，EPA和DHA可能对糖尿病性骨质减少有效，但要阐明确切机制，还需要进一步研究。
