囊泡出芽与融合的蛋白质机制。
The protein machinery of vesicle budding and fusion.
作者信息
Rothman J E
机构信息
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.
出版信息
Protein Sci. 1996 Feb;5(2):185-94. doi: 10.1002/pro.5560050201.
Abstract
A general protein machinery that buds and fuses transport vesicles is harnessed to generate the complex web of intracellular transport pathways critical for such diverse processes as cell growth, endocytosis, hormone release, and neurotransmission. With this appreciation, the challenge of understanding the precise molecular mechanisms of these many facets of cell biology has been reduced to a series of problems in protein structure and chemistry.
摘要
一种用于出芽和融合运输小泡的通用蛋白质机制被用于构建细胞内运输途径的复杂网络，这些途径对于细胞生长、内吞作用、激素释放和神经传递等多种不同过程至关重要。基于这种认识，理解细胞生物学这些多方面精确分子机制的挑战已简化为一系列蛋白质结构和化学问题。
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本文引用的文献
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Adaptins.衔接蛋白
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Binding of coatomer to Golgi membranes requires ADP-ribosylation factor.衣被蛋白与高尔基体膜的结合需要 ADP 核糖基化因子。
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The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein.AP-1网格蛋白衔接颗粒与高尔基体膜的结合需要一种小GTP结合蛋白——ADP核糖基化因子。
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Bos1p, an integral membrane protein of the endoplasmic reticulum to Golgi transport vesicles, is required for their fusion competence.Bos1p是内质网到高尔基体运输囊泡的一种整合膜蛋白，是其融合能力所必需的。
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Two distinct populations of ARF bound to Golgi membranes.两种不同的ARF群体与高尔基体膜结合。
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Budding from Golgi membranes requires the coatomer complex of non-clathrin coat proteins.从高尔基体膜出芽需要非网格蛋白包被蛋白的包被蛋白复合物。
Nature. 1993 Apr 15;362(6421):648-52. doi: 10.1038/362648a0.
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SNAP family of NSF attachment proteins includes a brain-specific isoform.NSF附着蛋白的SNAP家族包括一种脑特异性同工型。
Nature. 1993 Mar 25;362(6418):353-5. doi: 10.1038/362353a0.
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SNAP receptors implicated in vesicle targeting and fusion.参与囊泡靶向和融合的SNAP受体。
Nature. 1993 Mar 25;362(6418):318-24. doi: 10.1038/362318a0.
9
Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum.内质网出芽形成囊泡过程中对一种GTP酶激活蛋白的需求。
Science. 1993 Mar 5;259(5100):1466-8. doi: 10.1126/science.8451644.
10
Domain structure of an N-ethylmaleimide-sensitive fusion protein involved in vesicular transport.参与囊泡运输的N-乙基马来酰亚胺敏感融合蛋白的结构域结构。
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