Wang H, Cui J, Wang X, Wang Y
Department of Diagnosis, PUMC Hospital, Beijing.
Chin Med Sci J. 1995 Dec;10(4):223-5.
In this study, we characterized specifically-stained sera from patients with systemic lupus erythematosus (SLE) which had been shown to display the homogeneous or peripheral region of nuclei by indirect immunofluorescence (IIF). By western blotting, we demonstrated that in some cases there was a correlation between the peripheral or homogenous. IIF staining of nuclei by sera from patients with SLE and the presence of autoantibodies to lamins. Here we first report the presence of 2.2% anti-lamin autoantibodies in the sera among the 174 patients with SLE in China.
在本研究中，我们对系统性红斑狼疮（SLE）患者的特异性染色血清进行了特征分析，这些血清经间接免疫荧光法（IIF）检测显示可呈现细胞核的均质或周边区域。通过蛋白质印迹法，我们证明在某些情况下，SLE患者血清对细胞核的周边或均质IIF染色与抗核纤层蛋白自身抗体的存在之间存在相关性。在此我们首次报道在中国174例SLE患者的血清中抗核纤层蛋白自身抗体的存在率为2.2%。
