O'Dell B L, Reynolds G, Reeves P G
J Nutr. 1977 Jul;107(7):1222-8. doi: 10.1093/jn/107.7.1222.
At or near term, zinc deficient pregnant rats are depressed and exhibit difficult and extended parturition with excessive bleeding. This investigation was designed to develop objective measures of this pathology and to apply these parameters to the assessment of possible interrelationships of zinc with aldosterone and the prostaglandins. Female rats were fed during gestation a low zinc diet based on soybean protein (less than 1 ppm Zn) or the same diet supplemented with zinc (100ppm). Some of the rats were treated with aldosterone or aspirin, a prostaglandin inhibitor. Following parturition, both body temperature and blood pressure were depressed in the zinc deficient dams. Bleeding time and blood loss were also increased. Plasma potassium value were slightly elevated, adrenal weights increased and thymus weights decreased. Aldosterone had no effect on the incidence of the postpartum illness: temperature and blood pressure were unchanged. Toxic doses of aspirin produced pathologic signs analogous to those of zinc deficiency, including extended gestation period, difficult and prolonged parturition, excess bleeding, and low blood pressure and rectal temperature. The results suggest a role for zinc in prostaglandin metabolism.
在足月或接近足月时，缺锌的怀孕大鼠会出现抑郁，分娩困难且产程延长，伴有大量出血。本研究旨在开发针对这种病理状况的客观测量方法，并将这些参数应用于评估锌与醛固酮和前列腺素之间可能存在的相互关系。在妊娠期间，给雌性大鼠喂食基于大豆蛋白的低锌饮食（锌含量低于1 ppm）或添加了锌（100 ppm）的相同饮食。部分大鼠用醛固酮或阿司匹林（一种前列腺素抑制剂）进行处理。分娩后，缺锌母鼠的体温和血压均降低。出血时间和失血量也增加。血浆钾值略有升高，肾上腺重量增加，胸腺重量减轻。醛固酮对产后疾病的发生率没有影响：体温和血压未发生变化。高剂量的阿司匹林产生了与锌缺乏类似的病理体征，包括妊娠期延长、分娩困难且产程延长、出血过多以及低血压和直肠温度降低。结果表明锌在前列腺素代谢中发挥作用。
