Lazareth I, Priollet P
Service de Médecine vasculaire, Hôpital Saint-Joseph, Paris.
Ann Dermatol Venereol. 1995;122(9):575-8.
Necrotic angiodermitis is an uncommonly hypertensive ischemic ulceration. It usually occurs on the legs in elderly, hypertensive and sometimes diabetic patients. Its extensive and highly painful nature is characteristic. Currently, there is no simple effective treatment which is known to stop the development. We report the results of a patch graft method applied early before the angiodermitis develops into an advanced stage.
The technique was used in 13 consecutive patients with 16 episodes of necrotic angiodermitis. The graft was made 8 days (mean) after hospitalization.
The analgesic effect of the graft was apparent within the first days after the graft. The violet halo of extension disappeared a mean of 8 days after the graft. A second or even third graft was required in 8 of 16 episodes. Total cicatrization was obtained after a mean delay of 33 days.
Patch graft is a simple, low-cost, non invasive treatment which can be performed at the bedside and even in an outpatient clinic. This stops the extension of the necrotic angiodermitis and controls pain. Delay to cicatrization is shorter. The favourable effect of the graft could possibly be mediated by vasodilator peptides liberated by the graft tissue which would counteract the hypothetical vasospasm.
坏死性血管皮炎是一种罕见的高血压性缺血性溃疡。它通常发生在老年高血压患者,有时也见于糖尿病患者的腿部。其广泛且疼痛剧烈是其特点。目前,尚无已知的简单有效治疗方法能阻止其发展。我们报告了在血管皮炎发展到晚期之前早期应用补片移植方法的结果。
该技术应用于13例连续性坏死性血管皮炎患者的16次发作。移植在住院后平均8天进行。
移植后的头几天内,移植片的止痛效果明显。移植后平均8天,扩展的紫色晕圈消失。16次发作中有8次需要进行第二次甚至第三次移植。平均延迟33天后实现完全愈合。
补片移植是一种简单、低成本、非侵入性的治疗方法,可在床边甚至门诊进行。这可阻止坏死性血管皮炎的扩展并控制疼痛。愈合延迟时间较短。移植片的有益效果可能由移植组织释放的血管舒张肽介导,这些肽可抵消假设的血管痉挛。