Schwartzman R M, Kligman A M, Duclos D D
Department of Dermatology, University of Pennsylvania, Philadelphia 19104-6142, USA.
Br J Dermatol. 1996 Jan;134(1):64-70.
The skin of the Mexican hairless dog is covered with comedones, and this animal therefore provides a potentially useful model to assess the comedolytic activity of topical anti-acne drugs. We treated an animal with three different formulations of tretinoin for a 14-week period, and all produced a similar clinical response. There was a striking reduction in the number of comedones, and the skin became lighter and more uniform in colour. Histological changes were similar to those reported in humans treated with tretinoin, but a novel finding was incomplete neogenesis of hair follicles. We suggest that the Mexican hairless dog may be a useful model for screening novel molecules for retinoid activity.
墨西哥无毛犬的皮肤布满粉刺，因此这种动物为评估局部抗痤疮药物的溶粉刺活性提供了一个潜在有用的模型。我们用三种不同配方的维甲酸对一只动物进行了为期14周的治疗，所有治疗都产生了相似的临床反应。粉刺数量显著减少，皮肤颜色变浅且更加均匀。组织学变化与用维甲酸治疗的人类所报告的相似，但一个新发现是毛囊新生不完全。我们认为墨西哥无毛犬可能是筛选具有类视黄醇活性的新分子的有用模型。
