Kimura T, Doi K
Research Center, Nihon Nosan Kogyo. Co. Ltd., Ibaraki, Japan.
Exp Anim. 1996 Oct;45(4):377-84. doi: 10.1538/expanim.45.377.
In the first experiment, the skin sebum and humidity, perspiration ability of sweat glands, and histology of spontaneous comedones were examined in hairless descendants of Mexican hairless dogs. The skin of females showed lower humidity than that of males. Some animals with a large number of comedones exhibited remarkably high skin sebum scores. The comedones were distributed throughout the dorsal skin, and a cluster of lesions was found mainly in the limbs and prepuces. The sweat glands showed no perspiration in the sudorific test. Histologically, both infant and adult animals had lesions of micro- and/or "blackhead" comedones. Plugged follicles containing abundant keratic substances associated well-developed sebaceous glands. Spontaneous comedones in the skin of hairless dogs were grossly and histologically similar to the acne vulgaris observed in human beings. The skin of some adult animals showed a large number of protrusive comedones which were solid cystic structures containing organized substances. In the second experiment, three kinds of antiacne agents (sulfur and camphor, sulfur and resorcinol, and ibuprofen piconol) were applied daily to the test sites for one month. These antiacne agents caused prominent extrusion of keratin plugs from follicular sites. The results suggest that the hairless dogs are a predictive model for evaluating the efficacy of antiacne agents proposed for acne treatment.
在第一个实验中，对墨西哥无毛犬的无毛后代的皮肤皮脂和湿度、汗腺的排汗能力以及自发性粉刺的组织学进行了检查。雌性动物的皮肤湿度低于雄性。一些粉刺数量较多的动物皮肤皮脂评分显著较高。粉刺分布于整个背部皮肤，主要在四肢和包皮处发现一簇病变。在发汗试验中，汗腺无排汗现象。组织学上，幼年和成年动物均有微粉刺和/或“黑头”粉刺病变。含有丰富角质物质的堵塞毛囊与发育良好的皮脂腺相关。无毛犬皮肤中的自发性粉刺在肉眼和组织学上与人类寻常痤疮相似。一些成年动物的皮肤出现大量突出的粉刺，这些粉刺是含有组织化物质的实性囊性结构。在第二个实验中，将三种抗痤疮药物（硫磺和樟脑、硫磺和间苯二酚以及吡考布洛芬）每天应用于测试部位，持续一个月。这些抗痤疮药物导致角质栓从毛囊部位显著挤出。结果表明，无毛犬是评估用于痤疮治疗的抗痤疮药物疗效的预测模型。
