McLaughlin J E, Urich H
J Pathol. 1977 Jan;121(1):19-26. doi: 10.1002/path.1711210104.
A retrospective study of four tumours of the peripheral nervous system originally diagnosed as neuroblastomas or ganglioneuroblastomas has been made. The patients have all survived since the original diagnosis. Evidence of residual tumour was seen only in one patient, and was associated with evidence of increasing histological differentiation over a period of time. Maturation of primitive cell types is known to alter the prognosis of neuroblastic tumours. It is suggested first, that even minimal evidence of maturation indicates a better prognosis. Second, that evidence of maturation may be uneven, small areas occurring in otherwise totally undifferentiated tumours, or, immature areas remaining even in apparently benign fully mature tumours; if these areas show maturation the prognosis remains good and the tumour should not be confused with a composite ganglioneuroblastoma. Third, that maturing tumours may behave in a malignant fashion, invade and metastasise, but but with maturation of the primary tumour and its metastases the ultimate prognosis may be better than the initial behaviour suggests.
对最初诊断为神经母细胞瘤或神经节神经母细胞瘤的四种周围神经系统肿瘤进行了回顾性研究。自最初诊断以来，所有患者均存活。仅在一名患者中发现残留肿瘤证据，且与一段时间内组织学分化增加的证据相关。已知原始细胞类型的成熟会改变神经母细胞瘤的预后。建议如下：第一，即使是极少量的成熟证据也表明预后较好。第二，成熟证据可能不均衡，在其他完全未分化的肿瘤中出现小面积成熟区域，或者即使在明显良性的完全成熟肿瘤中仍存在未成熟区域；如果这些区域显示成熟，预后仍然良好，且该肿瘤不应与复合性神经节神经母细胞瘤混淆。第三，正在成熟的肿瘤可能表现出恶性行为，发生侵袭和转移，但随着原发性肿瘤及其转移灶的成熟，最终预后可能比初始表现更好。
