A role for the Fas antigen in lupus?
作者信息
Singh A K
出版信息
Postgrad Med J. 1996 Jan;72(843):4-5. doi: 10.1136/pgmj.72.843.4.
Abstract
摘要
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The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.在正常小鼠中，Fas蛋白在CD4+CD8+胸腺细胞和活化的成熟淋巴细胞上高水平表达，但在狼疮易感品系MRL lpr/lpr小鼠中则不表达。
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Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.内源性逆转录病毒整合到凋亡基因中导致小鼠自身免疫性疾病。
J Exp Med. 1993 Aug 1;178(2):461-8. doi: 10.1084/jem.178.2.461.
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Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.lpr小鼠Fas抗原基因内含子中早期转座元件插入导致的异常转录。
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