Anders H J
Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany.
Lupus. 2005;14(6):417-22. doi: 10.1191/0961203305lu2102rr.
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is CpG-DNA/TLR9 interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA?
Toll样受体（TLR）-9可识别微生物DNA中的CpG基序。TLR9信号传导刺激先天性抗菌免疫，并调节适应性免疫反应，包括针对染色质的自身免疫，例如在系统性红斑狼疮（SLE）中。本综述总结了TLR9信号传导在狼疮中作用的现有数据，并讨论了基于这些观察结果产生的以下问题：1）CpG-DNA/TLR9相互作用是否参与狼疮感染诱导的疾病活动？2）疫苗佐剂中的CpG基序对狼疮患者有哪些风险？3）TLR9信号传导是否通过识别自身DNA参与狼疮的发病机制？
