Bull R H, Fenton D A, Mortimer P S
Department of Dermatology, St George's Hospital, London, U.K.
Br J Dermatol. 1996 Feb;134(2):307-12.
Peripheral oedema is commonly seen in the yellow nail syndrome (YNS). Contrast lymphangiography has shown abnormal collecting lymphatics in some patients with YNS. In this study, lymphatic function in the upper and lower limbs of 17 patients with YNS, in normal controls, and in patients with established classical lymphoedema, has been assessed using quantitative lymphoscintigraphy. Nine subjects with YNS had swelling of the legs and two had features typical of lymphoedema. The lymphatic drainage was significantly reduced in the legs of patients with YNS but not to the level seen in lymphoedema. Lymphatic function was also reduced in the arms in patients with YNS. Venous insufficiency did not contribute to the leg oedema. These results suggest that the underlying cause of YNS is not primarily a lymphatic abnormality. The lymphatic impairment associated with YNS appears to be secondary, and predominantly functional in nature, rather than due to structural changes.
外周性水肿常见于黄甲综合征（YNS）。对比淋巴管造影显示，部分YNS患者的集合淋巴管存在异常。在本研究中，采用定量淋巴闪烁造影术对17例YNS患者、正常对照者以及已确诊的典型淋巴水肿患者的上下肢淋巴功能进行了评估。9例YNS患者腿部肿胀，2例具有典型的淋巴水肿特征。YNS患者腿部的淋巴引流明显减少，但未降至淋巴水肿患者所见的水平。YNS患者手臂的淋巴功能也有所降低。静脉功能不全并非导致腿部水肿的原因。这些结果表明，YNS的根本原因并非主要是淋巴异常。与YNS相关的淋巴损伤似乎是继发性的，主要是功能性的，而非结构改变所致。
