Patil A A, Andrews R, Torkelson R
University of Nebraska Medical Center, Omaha, USA.
Stereotact Funct Neurosurg. 1995;64(3):123-33. doi: 10.1159/000098741.
Computed tomography (CT) scans provide three-dimensional information about intracranial structures, which can be used to place stereotactically guided radiofrequency (RF) lesions and destroy a targeted volume of tissue. This technique was used for lesioning of the corpus callosum (CC) or the amygdala-hippocampus complex (AHC) in 9 patients with intractable seizures. The procedures were monitored by intraoperative CT scans. Lesions were made in the AHC in 7 patients and the CC in 2 patients. In addition, multiple subpial transection (MST) was performed in 6 patients. The longest follow-up is 29 months with a median of 19 months. Five patients (56%) are free of seizures, 3 patients (33%) have greater than 90% reduction in seizure activity and 1 patient (11%) has greater than 50% but at most 90% reduction in seizure activity. There were no complications except for temporary hemiparesis following MST in 1 patient. The results suggest that stereotactic volumetric RF lesioning of the AHC and the CC may be safe and effective in controlling intractable seizures.
计算机断层扫描（CT）可提供颅内结构的三维信息，这些信息可用于立体定向引导下放置射频（RF）损伤灶并破坏目标组织体积。该技术用于9例难治性癫痫患者的胼胝体（CC）或杏仁核 - 海马复合体（AHC）损伤。手术过程由术中CT扫描监测。7例患者在AHC进行了损伤，2例患者在CC进行了损伤。此外，6例患者进行了多处软膜下横切术（MST）。最长随访时间为29个月，中位数为19个月。5例患者（56%）无癫痫发作，3例患者（33%）癫痫活动减少超过90%，1例患者（11%）癫痫活动减少超过50%但最多为90%。除1例患者在MST后出现暂时性偏瘫外，无其他并发症。结果表明，AHC和CC的立体定向容积性RF损伤在控制难治性癫痫方面可能是安全有效的。
