Tanaka T, Hashizume K, Sawamura A, Yoshida K, Tsuda H, Hodozuka A, Nakai H
Department of Neurosurgery, Asahikawa Medical College, Asahikawa, Japan.
Stereotact Funct Neurosurg. 2001;77(1-4):239-44. doi: 10.1159/000064621.
Epilepsy surgery, as is employed for the management of intractable seizures, was performed in animals harboring a seizure focus induced by a local application of kainic acid (KA). Amygdalo-hippocampectomy failed to stop spontaneous seizures in the contralateral hippocampus. Callosotomy inhibited seizure propagation to the contralateral sensori-motor cortex. However, epileptic activity ipsilateral to the focus, including subcortical structures, persisted even after the callosotomy. Multiple subpial transection (MST) around the epileptic cortical focus suppressed the seizure activity of the cortex. However, seizure propagations in subcortical structures remained, even after MST. Nefiracetam (a new nootropic agent) was tested in these models, and its promising effect on the intractable extratemporal epilepsy is reported.
癫痫手术用于治疗难治性癫痫发作，在通过局部应用 kainic 酸（KA）诱导产生癫痫病灶的动物身上进行。杏仁核 - 海马切除术未能阻止对侧海马的自发性癫痫发作。胼胝体切开术抑制癫痫发作向对侧感觉运动皮层的传播。然而，即使在胼胝体切开术后，癫痫病灶同侧（包括皮质下结构）的癫痫活动仍持续存在。在癫痫皮质病灶周围进行多次软膜下横切术（MST）可抑制皮质的癫痫活动。然而，即使在 MST 术后，皮质下结构中的癫痫发作传播仍存在。在这些模型中对奈非西坦（一种新型促智药）进行了测试，并报告了其对难治性颞叶外癫痫的有前景的效果。
