Patil A A, Kumar P, Leibrock L G
Section of Neurosurgery, University of Nebraska Medical Center, Omaha, USA.
Stereotact Funct Neurosurg. 1995;64(3):139-52. doi: 10.1159/000098743.
125I seeds can deliver a very high dose of radiation (100-500 Gy) to a well-circumscribed area over their average life of 87 days, which enable them to destroy slow-growing extra-axial tumors after permanent implantation. Stereotactic implantation of 125I seeds was performed in 26 patients with extra-axial tumors, with a median follow-up of 32 months. No acute morbidity or mortality resulted from the procedure. Cranial nerve involvement in 5 patients was the only delayed complication. One patient developed radionecrosis outside the range of 125I dose distribution, which was felt to be due to the hyperfractionated external radiation the patient had received prior to 125I seed placement. All 26 patients showed tumor regression. The results indicate that this form of treatment is relatively safe and effective in the management of extra-axial tumors.
125I 粒子在其平均87天的生存期内能够向界限清晰的区域传递非常高的辐射剂量（100 - 500戈瑞），这使得它们在永久性植入后能够破坏生长缓慢的轴外肿瘤。对26例轴外肿瘤患者进行了125I粒子立体定向植入，中位随访时间为32个月。该操作未导致急性发病或死亡。仅5例患者出现的颅神经受累是唯一的延迟并发症。1例患者在125I剂量分布范围外发生放射性坏死，认为这是由于该患者在125I粒子植入前接受了超分割外照射所致。所有26例患者均显示肿瘤退缩。结果表明，这种治疗方式在轴外肿瘤的治疗中相对安全有效。
