Tanokuchi S, Okada S, Ota Z
Third Department of Internal Medicine, Okayama University Medical School, Japan.
J Int Med Res. 1995 Nov-Dec;23(6):423-30. doi: 10.1177/030006059502300603.
The factors that influence the severity of large vessel pathology in patients with non-insulin-dependent diabetes mellitus (NIDDM) were investigated in 154 randomly selected patients. Measurements of aortic pulse-wave velocity were used to quantify the severity of large vessel pathology. The results showed that of the 20 variables considered, age, systolic blood pressure, duration of disease and serum creatinine were all significantly correlated with pulse-wave velocity. Multiple regression analysis with pulse-wave velocity as the criterion variable showed that age, systolic and diastolic blood pressures were all significant explanatory variables, with age carrying the greatest weight. The findings suggest that controlling blood pressure is most important as a means of containing large vessel pathology in patients with NIDDM.
在154例随机选取的非胰岛素依赖型糖尿病（NIDDM）患者中，对影响大血管病变严重程度的因素进行了研究。采用主动脉脉搏波速度测量来量化大血管病变的严重程度。结果显示，在考虑的20个变量中，年龄、收缩压、病程和血清肌酐均与脉搏波速度显著相关。以脉搏波速度作为标准变量的多元回归分析表明，年龄、收缩压和舒张压均为显著的解释变量，其中年龄的权重最大。研究结果表明，控制血压作为遏制NIDDM患者大血管病变的手段最为重要。
