Battersby C, Hartley K, Fletcher A F, Markowe H J, Styles W, Sapper H, Bulpitt C J
Division of Geriatric Medicine, Royal Postgraduate Medical School, London, UK.
J Hum Hypertens. 1995 Dec;9(12):981-6.
The aim of this case-control community study was to determine whether there was a difference in quality of life between hypertensive subjects and matched normotensive controls. Cases aged 40-79 years were randomly selected from a hypertensive register and matched with controls for age, sex, ethnicity and health centre. Cases had phase V diastolic blood pressure (DBP) > or = 100 mm Hg or systolic blood pressure (SBP) > or = 180 mm Hg, or were on anti-hypertensive medication. Controls had DBP < or = 90 mm Hg and no record of raised BP or anti-hypertensive treatment within the past year. Quality of life was measured by self-administered questionnaire. Data from 90 matched pairs, average age 62 years, with 47% men, were analysed; 80 hypertensive subjects were on anti-hypertensive medication. Hypertensive subjects showed an impairment in well-being compared with controls. They had a lower Health Status Index, had more sickness absence from work, greater symptomatic complaint and impaired psychological well-being. Relatives also reported a poorer quality of life in the hypertensive subjects. This impairment could be a result of the disease, adverse effects of drug treatment or to the effects of labelling.
这项病例对照社区研究的目的是确定高血压患者与匹配的血压正常对照组在生活质量上是否存在差异。年龄在40 - 79岁的病例从高血压登记册中随机选取，并在年龄、性别、种族和健康中心方面与对照组进行匹配。病例的舒张压（DBP）处于Ⅴ期且≥100 mmHg或收缩压（SBP）≥180 mmHg，或正在接受抗高血压药物治疗。对照组的DBP≤90 mmHg，且在过去一年中没有血压升高或抗高血压治疗的记录。生活质量通过自我填写问卷进行测量。对90对匹配对象的数据进行了分析，平均年龄62岁，男性占47%；80名高血压患者正在接受抗高血压药物治疗。与对照组相比，高血压患者的幸福感受损。他们的健康状况指数较低，因病缺勤更多，有更多的症状性主诉，心理健康状况受损。亲属也报告说高血压患者的生活质量较差。这种损害可能是疾病、药物治疗的不良反应或标签效应的结果。
