Yeko T R, Rao P S, Parsons A K, Mayer J C, Graham L B, Maroulis G B
University of South Florida College of Medicine, Department of Obstetrics and Gynecology, Tampa 33606, USA.
Hum Reprod. 1995 Nov;10(11):2872-4. doi: 10.1093/oxfordjournals.humrep.a135810.
The objective of this study was to examine the relationship between the concentrations of oestradiol and progesterone on the one hand and atrial natriuretic peptide (ANP) concentrations on the other, during the follicular and luteal phases of spontaneous and gonadotrophin-stimulated ovulatory menstrual cycles. A total of 27 ovulatory women undergoing either a spontaneous (n = 9) or a gonadotrophin-stimulated (n = 18) cycle were selected for inclusion in this study. In comparison with spontaneous cycles, gonadotrophin-stimulated cycles had increased peak follicular oestradiol (mean +/- SE; 937 +/- 150 versus 195 +/- 18 pg/ml; P < 0.05) and midluteal progesterone (mean +/- SE; 44.0 +/- 7.4 versus 14.1 +/- 2.4 ng/ml; P < 0.05) concentrations. There were no differences in the circulating ANP concentrations between the follicular and luteal phases of the menstrual cycle. Despite the increased oestradiol and progesterone concentrations following gonadotrophin stimulation, no difference in ANP concentrations was seen between stimulated and spontaneous cycles. There was no correlation between circulating concentrations of oestradiol, progesterone (at physiological and supraphysiological concentrations) and ANP throughout the menstrual cycle.
本研究的目的是在自发排卵和促性腺激素刺激的排卵月经周期的卵泡期和黄体期，研究雌二醇和孕酮浓度与心房利钠肽（ANP）浓度之间的关系。共有27名经历自发周期（n = 9）或促性腺激素刺激周期（n = 18）的排卵女性被纳入本研究。与自发周期相比，促性腺激素刺激周期的卵泡期雌二醇峰值（平均值±标准误；937±150对195±18 pg/ml；P < 0.05）和黄体中期孕酮（平均值±标准误；44.0±7.4对14.1±2.4 ng/ml；P < 0.05）浓度升高。月经周期的卵泡期和黄体期之间循环ANP浓度没有差异。尽管促性腺激素刺激后雌二醇和孕酮浓度升高，但刺激周期和自发周期之间的ANP浓度没有差异。在整个月经周期中，雌二醇、孕酮（生理和超生理浓度）和ANP的循环浓度之间没有相关性。
