人类神经母细胞瘤中可释放的VCN唾液酸和神经节苷脂

VCN-releasable sialic acid and gangliosides in human neuroblastomas.

作者信息

Shochat S J, Abt A B, Schengrund C L

出版信息

J Pediatr Surg. 1977 Jun;12(3):413-8. doi: 10.1016/0022-3468(77)90019-7.

Abstract

The ganglioside pattern and VCN-releasable sialic acid residues of six human neuroblastomas were studied. There was no correlation between VCN-releasable sialic acid and prognosis. The ganglioside patterns were more complex in those cases with an expected good prognosis as reflected by the presence of trisialoganglioside. The complexity of the ganglioside pattern did not always correlate with the histologic grade of the tumor. These results suggest the ganglioside pattern may serve as a chemical marker for predicting the prognosis in patients with neuroblastomas.

摘要

对6例人类神经母细胞瘤的神经节苷脂模式和可从VCN释放的唾液酸残基进行了研究。可从VCN释放的唾液酸与预后之间没有相关性。在那些预期预后良好的病例中，神经节苷脂模式更为复杂，这可通过三唾液酸神经节苷脂的存在反映出来。神经节苷脂模式的复杂性并不总是与肿瘤的组织学分级相关。这些结果表明，神经节苷脂模式可能作为预测神经母细胞瘤患者预后的化学标志物。