Baley G J, Peck G E, Banker G S
J Pharm Sci. 1977 May;66(5):696-9. doi: 10.1002/jps.2600660522.
Alkyltrimethylammonium bromides of selected chain length were synthesized and characterized with respect to their bactericidal properties. A partitioning method was developed, and the aqueous phases of the partitioned systems were evaluated for their antibacterial activity against Staphylococcus aureus. The relationships between the quaternary ammonium compound chain length and the aliphatic alcohol chain length were determined. The effect of selected hydrocarbons on the bactericidal effectiveness of the systems was studied. Cream systems corresponding to the partitioned systems were prepared and evaluated against S. aureus. The relationship between the aqueous phase concentration of the bactericidal agent was studied, and a correlation was shown between the bactericidal activity of the partitioned systems and cream systems.
合成了选定链长的烷基三甲基溴化铵，并对其杀菌性能进行了表征。开发了一种分配方法，并评估了分配体系水相针对金黄色葡萄球菌的抗菌活性。确定了季铵化合物链长与脂肪醇链长之间的关系。研究了选定的碳氢化合物对体系杀菌效果的影响。制备了与分配体系相对应的乳膏体系，并针对金黄色葡萄球菌进行了评估。研究了杀菌剂水相浓度之间的关系，并表明分配体系和乳膏体系的杀菌活性之间存在相关性。
