Togashi Naoko, Shiraishi Akiko, Nishizaka Miki, Matsuoka Keisuke, Endo Kazutoyo, Hamashima Hajime, Inoue Yoshihiro
Department of Microbiology, Showa Pharmaceutical University, Machida, 194-8543 Tokyo, Japan.
Molecules. 2007 Feb 5;12(2):139-48. doi: 10.3390/12020139.
The antibacterial activity against Staphylococcus aureus of long-chain fatty alcohols was investigated, with a focus on normal alcohols. The antibacterial activity varied with the length of the aliphatic carbon chain and not with the water/octanol partition coefficient. 1-Nonanol, 1-decanol and 1-undecanol had bactericidal activity and membrane-damaging activity. 1-Dodecanol and 1-tridecanol had the highest antibacterial activity among the long-chain fatty alcohols tested, but had no membrane-damaging activity. Consequently, it appears that not only the antibacterial activity but also the mode of action of long-chain fatty alcohols might be determined by the length of the aliphatic carbon chain.
研究了长链脂肪醇对金黄色葡萄球菌的抗菌活性，重点是正构醇。抗菌活性随脂肪族碳链长度而变化，与水/辛醇分配系数无关。1-壬醇、1-癸醇和1-十一醇具有杀菌活性和膜损伤活性。在测试的长链脂肪醇中，1-十二醇和1-十三醇具有最高的抗菌活性，但没有膜损伤活性。因此，似乎长链脂肪醇的抗菌活性和作用方式都可能由脂肪族碳链的长度决定。
