Walter E A, Bowden R A
Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
Infect Dis Clin North Am. 1995 Dec;9(4):823-47.
Bone marrow transplantation (BMT) is widely used in the treatment of myelodysplastic disorders and leukemia. Despite improvements in patient management, infection as a consequence of the immunodeficiency states that follow BMT remains a significant cause of morbidity and mortality. This article provides an overview of the major infections after BMT with an emphasis on new developments in diagnosis, treatment, and prophylaxes that have occurred in recent years.
骨髓移植(BMT)广泛应用于骨髓增生异常综合征和白血病的治疗。尽管患者管理有所改善,但骨髓移植后因免疫缺陷状态导致的感染仍然是发病和死亡的重要原因。本文概述了骨髓移植后的主要感染情况,重点介绍了近年来在诊断、治疗和预防方面的新进展。