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移植后淋巴细胞增生性疾病

Post-transplant lymphoproliferative disorder.

作者信息

Basgoz N, Preiksaitis J K

机构信息

Division of Infectious Diseases, Massachusetts General Hospital, Boston, 02114, USA.

出版信息

Infect Dis Clin North Am. 1995 Dec;9(4):901-23.

PMID:8747772
Abstract

This article discusses the virology of Epstein-Barr virus (EBV) and provides an overview of the disease states associated with the virus, describes how the immunology of EBV infection provides for control in the normal host, and reviews what is currently known about post-transplant lymphoproliferative disorder (PTLD), including evidence for EBV in the pathogenesis of PTLD, risk factors for its development, clinical presentation, methods for diagnosis, pathology, treatment, and current and future preventive strategies.

摘要

本文讨论了爱泼斯坦-巴尔病毒(EBV)的病毒学,概述了与该病毒相关的疾病状态,描述了EBV感染的免疫学如何在正常宿主中实现控制,并综述了目前关于移植后淋巴细胞增殖性疾病(PTLD)的已知情况,包括EBV在PTLD发病机制中的证据、其发生的危险因素、临床表现、诊断方法、病理学、治疗以及当前和未来的预防策略。

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