Rooney C M, Smith C A, Heslop H E
Department of Virology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mol Med Today. 1997 Jan;3(1):24-30. doi: 10.1016/S1357-4310(96)10054-X.
Epstein-Barr virus (EBV) is a latent herpesvirus that is associated with a number of tumors. EBV-infected cells show three patterns of latency ranging from type 1, where only one EBV-encoded antigen is expressed, to type 3, where all nine latent cycle proteins encoded by EBV are expressed. Malignancies exhibiting the type 3 latency pattern are highly immunogenic and occur only in immunocompromised patients. It has recently been shown that adoptive immunotherapy with EBV-specific cytotoxic T lymphocytes is an effective therapy for such tumors. Immunotherapy strategies and approaches to increase tumor immunogenicity are now being evaluated in tumors expressing type 2 latency.
爱泼斯坦-巴尔病毒（EBV）是一种潜伏性疱疹病毒，与多种肿瘤相关。受EBV感染的细胞表现出三种潜伏模式，从仅表达一种EBV编码抗原的1型，到表达EBV编码的所有九种潜伏周期蛋白的3型。表现出3型潜伏模式的恶性肿瘤具有高度免疫原性，且仅发生在免疫功能低下的患者中。最近有研究表明，采用EBV特异性细胞毒性T淋巴细胞进行过继性免疫治疗是治疗此类肿瘤的有效方法。目前正在对表达2型潜伏的肿瘤评估增加肿瘤免疫原性的免疫治疗策略和方法。
