Yadav C L, Kumar R, Uppal R P, Verma S P
Department of Veterinary Parasitology, CCS Haryana Agricultural University, Hisar, India.
Vet Parasitol. 1995 Dec;60(3-4):355-60. doi: 10.1016/0304-4017(95)00769-2.
Multiple resistance to benzimidazoles (fenbendazole, albendazole and mebendazole) in a strain of Haemonchus contortus in sheep was detected on a farm where fenbendazole resistance had already been identified. Following a faecal egg count reduction test, this was confirmed by both critical and controlled anthelmintic tests. Different groups of sheep infected naturally or given an experimental infection with the fenbendazole-resistant strain were treated with the recommended doses of various anthelmintics. Compared to the control group, percentage reductions in faecal egg counts of sheep treated with fenbendazole, albendazole, mebendazole, levamisole and morantel varied between 56% and 81% and worm counts between 71% and 86%. The results indicate the presence of multiple anthelmintic resistance in this strain of H. contortus on this farm. Sheep treated with ivermectin and closantel showed 100% reductions in faecal egg and worm counts, suggesting high efficacy of these drugs against the population of H. contortus on this farm.
在一个已发现芬苯达唑耐药性的养羊场中，检测到一株捻转血矛线虫对苯并咪唑类药物（芬苯达唑、阿苯达唑和甲苯达唑）具有多重耐药性。在进行粪便虫卵计数减少试验后，通过关键驱虫试验和对照驱虫试验均证实了这一点。将自然感染或经实验感染了耐芬苯达唑菌株的不同组绵羊，用各种驱虫药的推荐剂量进行治疗。与对照组相比，用芬苯达唑、阿苯达唑、甲苯达唑、左旋咪唑和噻嘧啶治疗的绵羊粪便虫卵计数减少百分比在56%至81%之间，虫体计数减少百分比在71%至86%之间。结果表明该农场的这株捻转血矛线虫存在多重驱虫药耐药性。用伊维菌素和氯氰碘柳胺治疗的绵羊粪便虫卵和虫体计数减少了100%，表明这些药物对该农场的捻转血矛线虫种群具有高效性。
