Simonová G, Novotný J, Novotný J, Vladyka V, Liscák R
Stereotactic and Radiation Neurosurgery Department, Hospital Na Homolce, Prague, Czech Republic.
Radiother Oncol. 1995 Nov;37(2):108-16. doi: 10.1016/0167-8140(95)01632-q.
The main aim of this study was to check feasibility of stereotactic radiotherapy, which is routinely practised on linear accelerators, using a fixed Leksell stereotactic frame and a Leksell Gamma Knife. The study refers to the first experiences with 48 patients treated by a fractionated regimen (in 2-6 days). Isoeffect relationships calculations based on the linear-quadratic model and the levels of applied radiation doses, taking into account radiobiology of the tumour, tumour volume, critical structures surrounding the treated lesion and other factors are discussed. The procedure for quality control during the whole fractionated regimen is described. The study has shown that stereotactic radiotherapy with the Leksell Gamma Knife is feasible. However, only early effects can be discussed and there are still questions remaining which should be carefully studied: tolerance doses for critical structures at fractionation, definition of an 'ideal' fractionation regimen, and justification of the linear-quadratic model in the case of stereotactic radiotherapy.
本研究的主要目的是检验立体定向放射治疗的可行性，该治疗在线性加速器上常规进行，使用固定的Leksell立体定向框架和Leksell伽玛刀。本研究涉及48例接受分次治疗方案（在2至6天内）患者的首次治疗经验。讨论了基于线性二次模型的等效效应关系计算以及所应用的辐射剂量水平，同时考虑了肿瘤的放射生物学、肿瘤体积、治疗病变周围的关键结构和其他因素。描述了整个分次治疗方案中的质量控制程序。研究表明，使用Leksell伽玛刀进行立体定向放射治疗是可行的。然而，目前只能讨论早期效应，仍有一些问题有待仔细研究：分次治疗时关键结构的耐受剂量、“理想”分次治疗方案的定义以及立体定向放射治疗情况下线性二次模型的合理性。
