Reiffers J
Laboratoire de Greffe de Moelle, URA CNRS 1456, Université de Bordeaux II, France.
Stem Cells. 1995 Dec;13 Suppl 3:19-22. doi: 10.1002/stem.5530130704.
Since our initial report of successful peripheral blood stem cell transplantation (PBSCT) in a patient with acute myeloid leukemia (AML), we have performed more than 300 PBSCTs; 49 of them were done for AML patients. PBSC mobilization (and collection) was influenced by the number of previous courses of chemotherapy and significantly increased when G-CSF was combined with chemotherapy for mobilization. Hematopoietic recovery (HR) was complete in every patient. The HR rate was influenced by the number of cells transplanted. Platelet recovery was significantly quicker for patients given G-CSF for mobilization. The outcome of patients transplanted in first or second remission was similar to that usually observed after bone marrow transplantation.
自从我们首次报道成功为一名急性髓系白血病（AML）患者进行外周血干细胞移植（PBSCT）以来，我们已经进行了300多次PBSCT；其中49次是为AML患者进行的。外周血干细胞动员（和采集）受既往化疗疗程数的影响，当粒细胞集落刺激因子（G-CSF）与化疗联合用于动员时，其显著增加。每位患者的造血恢复（HR）均已完成。HR率受移植细胞数量的影响。接受G-CSF动员的患者血小板恢复明显更快。首次或第二次缓解期移植患者的结局与骨髓移植后通常观察到的结局相似。
