O'Neill P J, Rahwan R G
J Pharm Sci. 1977 Jun;66(6):893-5. doi: 10.1002/jps.2600660648.
A modified assay for a neuroamine-derived tetrahydroisoquinoline, salsolinol, is presented. It combines the ease and rapidity of solvent extraction from brain tiessue with the sensitivity of electron-capture GLC. Detection of salsolinol (1,2,3,4-tetrahydro-1-methyl-6,7-isoquinolinediol), the alkaloid derived from condensation of dopamine and acetaldehyde, at levels of 5-10 ng/g of brain tissue is possible. The advantages afforded by the modifications are discussed in relation to existing procedures.
本文介绍了一种用于检测神经胺衍生的四氢异喹啉（salsolinol）的改良测定方法。该方法将从脑组织中进行溶剂萃取的简便性和快速性与电子捕获气相色谱法的灵敏度相结合。能够检测到脑组织中含量为5-10 ng/g的salsolinol（1,2,3,4-四氢-1-甲基-6,7-异喹啉二醇），即由多巴胺和乙醛缩合形成的生物碱。文中还结合现有方法讨论了这些改良所带来的优势。
