一项关于人脑区域中多巴胺及其衍生的萨索林醇和去甲萨索林醇水平的系统性区域研究。

A systematic regional study of dopamine and dopamine-derived salsolinol and norsalsolinol levels in human brain areas.

作者信息

Musshoff F, Schmidt P, Dettmeyer R, Priemer F, Wittig H, Madea B

机构信息

Institute of Legal Medicine, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.

出版信息

Forensic Sci Int. 1999 Oct 25;105(1):1-11. doi: 10.1016/s0379-0738(99)00110-3.

DOI:10.1016/s0379-0738(99)00110-3

PMID:10605071

Abstract

Dopamine and the dopamine-derived tetrahydroisoquinoline alkaloids salsolinol and norsalsolinol were measured by high-performance liquid chromatography with electrochemical detection in 15 regions of the human brain. The regional distribution of dopamine in 32 brains was similar to previous reports with highest concentrations in the basal ganglia, especially in the striatum, followed by the substantia nigra and the hypothalamus. Significant amounts of salsolinol and norsalsolinol were only found in these dopamine-rich areas, whereas in the other regions no alkaloids were detected. These findings suggest that the concentration of the substrate dopamine may determine the alkaloid level during in vivo formation.

摘要

采用高效液相色谱-电化学检测法，对人脑中15个区域的多巴胺以及多巴胺衍生的四氢异喹啉生物碱（去甲猪毛菜酚和猪毛菜酚）进行了测定。32个大脑中多巴胺的区域分布与之前的报道相似，浓度最高的区域是基底神经节，尤其是纹状体，其次是黑质和下丘脑。仅在这些富含多巴胺的区域发现了大量的去甲猪毛菜酚和猪毛菜酚，而在其他区域未检测到生物碱。这些发现表明，在体内形成过程中，底物多巴胺的浓度可能决定生物碱的水平。