Gudelsky G A, Moore K E
J Pharmacol Exp Ther. 1977 Jul;202(1):149-56.
A sensitive radioenzymatic procedure was used to quantify the effect of haloperidol on dopamine concentrations and rates of turnover in rat striatum, olfactory tubercle and median eminence, regions containing terminals of nigrostriatal, mesolimbic and tuberoinfundibular neurons, respectively. Haloperidol (2.5 mg/kg s.c.) did not alter the steady-state concentrations of dopamine in any of these brain regions at any time. Haloperidol increased dopamine turnover in the striatum and olfactory tubercle 2 and 8 hours after adminstration. The rate of dopamine turnover was increased only in the median eminence 16 and 24 hours after the administration of haloperidol, and effect which was blocked by hypophysectomy. Two other antipsychotic agents, clozapine and thioridazine, also increased dopamine turnover in the median eminence 16 hours after the first of two injections. These results provide evidence for the existence of hormonal neuronal feedback modulation of tuberoinfundibular dopaminergic neurons in contrast to the neuronal feedback modulation of nigrostriatal and mesolimbic neurons.
采用一种灵敏的放射酶法来量化氟哌啶醇对大鼠纹状体、嗅结节和正中隆起中多巴胺浓度及周转率的影响，这些区域分别含有黑质纹状体、中脑边缘和结节漏斗神经元的终末。氟哌啶醇（2.5毫克/千克，皮下注射）在任何时间均未改变这些脑区中任何一个区域多巴胺的稳态浓度。氟哌啶醇在给药后2小时和8小时增加了纹状体和嗅结节中多巴胺的周转率。仅在氟哌啶醇给药后16小时和24小时，正中隆起中多巴胺的周转率增加，垂体切除可阻断该效应。另外两种抗精神病药物氯氮平和硫利达嗪在两次注射中的首次注射后16小时也增加了正中隆起中多巴胺的周转率。这些结果为结节漏斗多巴胺能神经元存在激素神经元反馈调节提供了证据，这与黑质纹状体和中脑边缘神经元的神经元反馈调节形成对比。
