Böck J C, Henrikson O, Götze A H, Wlodarczyk W, Sander B, Felix R
Strahlenklinik, Virchow-Klinikum Medizinische Fakultät der Humboldt Universitat zu Berlin, Germany.
Invest Radiol. 1995 Dec;30(12):693-9.
To present a mathematic approach for the analysis of first-pass gadolinium (Gd)-DTPA kinetics and to validate the numerical tools using simulated and measured kinetics.
In a capillary plasma filter, pulsatile flow was varied between 7.4 and 12.6 mL/second. After contrast bolus injection, the arterial input curve and the residue curve were recorded simultaneously. Signal intensity versus time curves were converted to concentration versus time curves. By deconvolution of these curves and tracer kinetic analysis, the mean transit time of the contrast medium through the organ model was calculated.
A satisfactory correlation (r = 0.98) between the inverse of mean transit time and flow measured volumetrically was demonstrated.
The kinetic analysis of first-pass curves in an organ model indicates that this approach might be useful for in vivo assessment of organ blood flow.
提出一种用于分析首过钆（Gd）-二乙三胺五乙酸（DTPA）动力学的数学方法，并使用模拟和测量的动力学来验证数值工具。
在毛细管血浆滤器中，脉动流在7.4至12.6毫升/秒之间变化。在注射造影剂团注后，同时记录动脉输入曲线和残留曲线。将信号强度与时间曲线转换为浓度与时间曲线。通过对这些曲线进行去卷积和示踪剂动力学分析，计算造影剂通过器官模型的平均通过时间。
平均通过时间的倒数与通过体积测量的流量之间显示出令人满意的相关性（r = 0.98）。
器官模型中首过曲线的动力学分析表明，这种方法可能有助于体内评估器官血流。
