Muschick P, Wehrmann D, Schuhmann-Giampieri G, Krause W
Research Laboratories of Schering AG, Berlin, Germany.
Invest Radiol. 1995 Dec;30(12):745-53. doi: 10.1097/00004424-199512000-00009.
The study was designed to compare the hemodynamic effects of 11 iodinated contrast media (CM), including ionic (diatrizoate, ioxaglate), nonionic monomeric (iohexol, iopromide, iopamidol, iopentol, ioversol, iomeprol, ZK 139129), and nonionic dimeric (iotrolan, iodixanol) compounds.
Following left ventricular bolus injection of 1.2 g I/kg body weight in anesthetized rats, cardiohemodynamic parameters were measured.
Compared with the control group, except for blood pressure (BP), all CM showed a similar response regarding the direction of the cardiohemodynamic changes after CM injection. A biphasic change in BP was observed for diatrizoate and iodixanol, whereas all other CM showed a transient increase in BP being most pronounced for ioxaglate. No arrhythmias were detected. The increase in LVEDP was lowest for the isotonic dimeric CM iotrolan and iodixanol.
Only mild transient side effects were observed. Low osmolar, especially isotonic, dimeric CM show a clear benefit regarding cardiovascular side effects.
本研究旨在比较11种碘化造影剂（CM）的血流动力学效应，包括离子型（泛影葡胺、碘克沙酸）、非离子单体型（碘海醇、碘普罗胺、碘帕醇、碘喷托、碘佛醇、碘美普尔、ZK 139129）和非离子二聚体型（碘曲仑、碘克沙醇）化合物。
在麻醉大鼠中以1.2 g碘/千克体重经左心室大剂量注射后，测量心脏血流动力学参数。
与对照组相比，除血压（BP）外，所有造影剂注射后在心脏血流动力学变化方向上显示出相似的反应。泛影葡胺和碘克沙醇观察到血压呈双相变化，而所有其他造影剂显示血压短暂升高，碘克沙酸最为明显。未检测到心律失常。等渗二聚体型造影剂碘曲仑和碘克沙醇的左室舒张末压升高最低。
仅观察到轻微的短暂副作用。低渗，尤其是等渗的二聚体型造影剂在心血管副作用方面显示出明显优势。
