el-Ahmady O, el-Maraghy A, Ibrahim A, Ramzy S
Tumor Marker Oncology Research Center, Al-Azhar University, Cairo, Egypt.
Nutrition. 1995 Sep-Oct;11(5 Suppl):498-501.
Some environmental factors and diseases have been demonstrated to affect trace-element homeostasis. Ninety individuals were included in the present study (30 with bronchogenic carcinoma, 30 with some nonmalignant lung diseases, and 30 normal healthy controls). Serum copper, zinc, and iron levels were determined by the atomic absorption spectrophotometry. Results of this study revealed that serum copper was markedly elevated in benign lung diseases followed by bronchial carcinoma. Serum zinc was significantly reduced, whereas serum iron was not significantly decreased in both benign and malignant lung diseases compared to normal healthy controls. As to the sensitivity of the studied elements in lung disorders, neither serum copper nor serum iron can be used to detect benign or malignant diseases. Serum zinc and copper/zinc ratios showed reasonable values for prediction of pulmonary diseases but cannot be recommended as tumor markers in lung cancer.
一些环境因素和疾病已被证明会影响微量元素的稳态。本研究纳入了90名个体（30例支气管源性癌患者、30例患有某些非恶性肺部疾病的患者以及30名正常健康对照）。采用原子吸收分光光度法测定血清铜、锌和铁水平。本研究结果显示，良性肺部疾病患者的血清铜显著升高，其次是支气管癌患者。与正常健康对照相比，良性和恶性肺部疾病患者的血清锌均显著降低，而血清铁无显著下降。至于所研究元素在肺部疾病中的敏感性，血清铜和血清铁均不能用于检测良性或恶性疾病。血清锌和铜/锌比值在预测肺部疾病方面显示出合理的值，但不能推荐作为肺癌的肿瘤标志物。
