Eissa S, Khalifa A, Laban M, Mohamed M K, Elian A
Oncology Diagnostic Unit (Biochemistry Department), Ain Shams Faculty of Medicine, Cairo, Egypt.
Nutrition. 1995 Sep-Oct;11(5 Suppl):622-6.
The prognosis in ovarian cancer patients remains poor, and there is a need to identify patients who are less likely to respond to treatment. In a prospective study of patients with ovarian carcinoma treated by a standard protocol, variables such as age, tumor type, International Federation of Gynecology and Obstetrics stage, histologic grade, results from flow cytometry, receptors for estrogen (ER) and progesterone (PR), and serum CA 125 were correlated to relapse and survival. Univariate analysis revealed that stage, histologic grade, DNA ploidy, ER, PR, and CA 125 were of significant association to survival, but only stage, DNA ploidy, PR, and CA 125 were found to be of significant value to relapse. Multivariate analysis identified DNA ploidy as an independent prognostic variable for both relapse and survival.
卵巢癌患者的预后仍然很差，因此有必要识别出那些对治疗反应可能性较小的患者。在一项采用标准方案治疗的卵巢癌患者前瞻性研究中，年龄、肿瘤类型、国际妇产科联盟分期、组织学分级、流式细胞术结果、雌激素受体（ER）和孕激素受体（PR）以及血清CA 125等变量与复发和生存情况相关。单因素分析显示，分期、组织学分级、DNA倍体、ER、PR和CA 125与生存显著相关，但仅分期、DNA倍体、PR和CA 125被发现对复发具有显著价值。多因素分析确定DNA倍体是复发和生存的独立预后变量。
