A velocity correlation method for measuring vascular compliance using MR imaging.

A method for estimating vascular compliance using MR velocity imaging is presented. The technique combines an analysis of pulse propagation, based on spatially averaged equations of continuity and momentum, together with phase-contrast velocity measurements to estimate the compliance from a correlation of second-order spatial and temporal velocity derivatives. The technique can be applied in the presence of reflected flow waves and uses velocity data acquired throughout the entire cardiac cycle. The accuracy of the technique was assessed in distensible vessel phantoms spanning a physiological range of compliance through a comparison with compliance estimates obtained using high-resolution MR imaging and pressure transducers. The mean error of all measurements was found to be 0.04 +/- 0.02% per mm Hg, with the relative errors ranging from 1.2% to 46%. Error was found to decrease as the temporal sampling rate and/or image plane separation were increased. This suggests that an accurate hemodynamic evaluation of a vessel's elastic properties is feasible with MR velocity imaging techniques.