Moody K M, Adler N T
Institute of Neurological Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Horm Behav. 1995 Dec;29(4):571-80. doi: 10.1006/hbeh.1995.1287.
The effect of ovariectomy, hysterectomy, and cerviectomy on systemic oxytocin-PGE2 induced facilitation of lordosis behavior was examined in estrogen and progesterone treated rats. Females were injected with 0.25 micrograms estradiol benzoate for 3 days, followed by 500 micrograms progesterone on day 4, 4 hr prior to behavioral testing. Ten minutes before behavioral testing with a male, females were injected systemically with either oxytocin (2.1, 4.2, or 8.4 micrograms); PGE2 (0.05, 0.10, or 0.20 micrograms); concomitant administration of both oxytocin and PGE2; or physiological saline. Oxytocin (2.1 micrograms) or PGE2 (0.05 micrograms) significantly increased lordosis behavior in ovariectomized females; however, neither had any facilitatory effect in hysterectomized animals. Facilitated lordosis behavior was only reinstated in hysterectomized females that received concomitant administration of 2.1 micrograms oxytocin plus 0.05 micrograms PGE2. This latter dose also resulted in a further potentiation of lordosis behavior in ovariectomized animals, compared to 2.1 micrograms oxytocin or 0.05 micrograms PGE2 alone. Concomitant administration of oxytocin and PGE2 at all doses had no facilitatory effect on lordosis behavior in cerviectomized animals. These results suggest that the uterus and the cervix may be important components of a peripheral mechanism by which systemic oxytocin and/or PGE2 induce facilitated lordosis behavior in female rats.
在接受雌激素和孕酮处理的大鼠中，研究了卵巢切除术、子宫切除术和宫颈切除术对全身催产素 - 前列腺素E2诱导的脊柱前凸行为促进作用的影响。雌性大鼠连续3天注射0.25微克苯甲酸雌二醇，在行为测试前4小时的第4天注射500微克孕酮。在用雄性大鼠进行行为测试前10分钟，雌性大鼠全身注射催产素（2.1、4.2或8.4微克）；前列腺素E2（0.05、0.10或0.20微克）；催产素和前列腺素E2同时给药；或生理盐水。催产素（2.1微克）或前列腺素E2（0.05微克）显著增加了去卵巢雌性大鼠的脊柱前凸行为；然而，两者对子宫切除的动物均无促进作用。仅在同时接受2.1微克催产素加0.05微克前列腺素E2给药的子宫切除雌性大鼠中，脊柱前凸行为促进作用得以恢复。与单独使用2.1微克催产素或0.05微克前列腺素E2相比，后一种剂量还导致去卵巢动物的脊柱前凸行为进一步增强。所有剂量的催产素和前列腺素E2同时给药对宫颈切除动物的脊柱前凸行为均无促进作用。这些结果表明，子宫和宫颈可能是全身催产素和/或前列腺素E2诱导雌性大鼠脊柱前凸行为促进作用的外周机制的重要组成部分。
