Huhman K L, Mougey E H, Moore T O, Meyerhoff J L
Department of Biology and Psychology, Georgia State University, Atlanta 30303, USA.
Horm Behav. 1995 Dec;29(4):581-92. doi: 10.1006/hbeh.1995.1291.
Following exposure to a stressor, plasma prolactin (PRL) rises in most species. The purpose of the present study was to examine the effect of social conflict or of footshock stress on PRL responsiveness in male Syrian hamsters. Contrary to expectations, PRL was significantly lower in subordinate hamsters than in their dominant opponents or in controls following one, five, or nine exposures to social conflict. Similarly, PRL was reduced in hamsters subjected to a mild footshock stressor. By contrast, adrenocorticotropin, another stress-responsive hormone, was elevated following exposure to each of these stressors. We also demonstrate that PRL release is inhibited by dopamine as it is in other species by showing that there is a dose-dependent increase in PRL release following treatment with the dopamine receptor blocker, domperidone.
在大多数物种中，暴露于应激源后，血浆催乳素（PRL）会升高。本研究的目的是检验社会冲突或足部电击应激对雄性叙利亚仓鼠PRL反应性的影响。与预期相反，在经历一次、五次或九次社会冲突后，从属仓鼠的PRL显著低于其占主导地位的对手或对照组。同样，受到轻度足部电击应激源作用的仓鼠的PRL也降低了。相比之下，另一种应激反应激素促肾上腺皮质激素在暴露于这些应激源中的每一种后都会升高。我们还证明，多巴胺会抑制PRL的释放，就像在其他物种中一样，这是通过表明用多巴胺受体阻滞剂多潘立酮治疗后PRL释放呈剂量依赖性增加来证明的。
