一种控制中枢性去传入性疼痛的新方法——脊髓鞘内注射巴氯芬。
A new approach to the control of central deafferentation pain--spinal intrathecal baclofen.
作者信息
Taira T, Kawamura H, Tanikawa T, Kawabatake H, Iseki H, Ueda A, Takakura K
机构信息
Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical College, Japan.
出版信息
Acta Neurochir Suppl. 1995;64:136-8. doi: 10.1007/978-3-7091-9419-5_30.
PMID:8748602
Abstract
We investigated the short-term effects of an intrathecal bolus injection of baclofen on central pain due to stroke or spinal cord injury. Pain relief was obtained in 64% of the patients. The effects developed 1-2 hours after the injection and continued for 10-24 hours. Both spinal segmental and supraspinal mechanisms may be involved in the production of baclofen-analgesia.
摘要
我们研究了鞘内注射巴氯芬对中风或脊髓损伤所致中枢性疼痛的短期影响。64%的患者疼痛得到缓解。注射后1 - 2小时出现效果，并持续10 - 24小时。脊髓节段性和脊髓上机制可能都参与了巴氯芬镇痛作用的产生。
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