Bodis-Wollner I, Antal A
Department of Neurology, State University of New York--Health Science Center at Brooklyn, USA.
J Neural Transm Suppl. 1995;45:67-74.
Diverse dopamine receptors have been identified in the primate retina. Evidence summarized from human and monkey retinal electrophysiological studies (ERG) suggests that separate D1 and D2 receptor activation results in stimulus dependent antagonistic effects. Studies were performed using Haloperidol, 1-sulpiride, CY 208-243 and dopamine. It is inferred that the antagonistic functions of D1 and D2 receptors synergistically determine the inverted U-shaped spatial contrast response function of the primate retina. An understanding of the logic performed by retinal D1 and D2 receptors may be useful to discern properties of the role of diverse dopamine receptors in basal ganglia DA circuits.
在灵长类动物视网膜中已鉴定出多种多巴胺受体。从人类和猴子的视网膜电生理研究（ERG）总结的证据表明，D1和D2受体的单独激活会产生刺激依赖性拮抗作用。使用氟哌啶醇、1-舒必利、CY 208-243和多巴胺进行了研究。据推断，D1和D2受体的拮抗功能协同决定了灵长类动物视网膜的倒U形空间对比度响应函数。了解视网膜D1和D2受体执行的逻辑可能有助于识别不同多巴胺受体在基底神经节多巴胺能回路中的作用特性。
