Strange P G
Biological Laboratory, The University, Canterbury, Kent, U.K.
Mov Disord. 1993 Jul;8(3):263-70. doi: 10.1002/mds.870080303.
At least five receptors for dopamine (D1-D5) have been recognised from molecular biological studies, and their pharmacological properties and brain localisations have been determined. The D1 and D2 subtypes are the principal subtypes in brain, and their cellular localisations in the caudate nucleus and putamen have been determined. With recent advances in the understanding of basal ganglia neuronal function, these localisation data enable insights into the mode of action of drugs used at present and in the future to treat Parkinson's disease.
分子生物学研究已识别出至少五种多巴胺受体（D1 - D5），并确定了它们的药理学特性和脑内定位。D1和D2亚型是脑中的主要亚型，且已确定它们在尾状核和壳核中的细胞定位。随着对基底神经节神经元功能认识的最新进展，这些定位数据有助于深入了解目前及未来用于治疗帕金森病的药物的作用方式。
