Kajimoto Y, Shirakawa O, Kuno T, Nishino N, Nakai H
Department of Psychiatry and Neurology, Kobe University School of Medicine, Japan.
J Neural Transm Gen Sect. 1995;100(3):257-62. doi: 10.1007/BF01276463.
Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia, and PCP-treated animals can serve as a model for schizophrenia. The effects of PCP on the gene expression of NVP-1, a novel Ca(2+)-binding protein, were studied in rats. After 24 hours, the NVP-1 mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca(2+)-binding protein may be involved in the pathology of PCP-induced psychosis and, presumably, schizophrenia.
苯环利定（PCP）会诱发一种与精神分裂症极为相似的拟精神病状态，用PCP处理过的动物可作为精神分裂症的模型。在大鼠中研究了PCP对一种新型钙结合蛋白NVP-1基因表达的影响。24小时后，伏隔核中的NVP-1 mRNA水平显著下降了42%。这一结果表明，钙结合蛋白的改变可能与PCP诱发的精神病以及推测的精神分裂症的病理过程有关。
